Angiopoietin-1 and Pulmonary Hypertension

Angiopoietin-1 and Pulmonary Hypertension

Our very existence depends on the air that we breathe, as well as the remarkable systems that have evolved to ensure that the oxygen we take into our lungs is efficiently delivered to the rest of the body via the bloodstream. When these systems begin to fail, life itself can become quite tenuous. Such failure occurs in pulmonary hypertension, a rare but serious disease whose pathophysiology rem...

Angiopoietin-1 and pulmonary hypertension: cause or cure?

Protective role of angiopoietin-1 in experimental pulmonary hypertension.

Angiopoietin-1 (Ang-1), a newly discovered ligand of the endothelial-specific tyrosine kinase receptor Tie-2, has been found to promote cell survival, vascular maturation, and stabilization. We hypothesized that Ang-1 gene transfer to the pulmonary microcirculation would improve pulmonary hemodynamics and vascular remodeling in experimental pulmonary hypertension. Rat pulmonary artery smooth mu...

Hypertension, Vascular Rarefaction and Angiopoietin-1

Hypertension is a very common but incompletely understood disease, especially in its pathogenesis and vascular complications occurring in the cardiovascular research filed. There are many explanations for pathological mechanisms in hypertension, including adrenergic over-reactivity, renin-angiotensin-aldosteron system abnormality and constitutionalgenetic-environmental factors. Recently emergin...

Circulating Angiopoietin-1 Is Not a Biomarker of Disease Severity or Prognosis in Pulmonary Hypertension

BACKGROUND Circulating angiopoietin-1 (Ang-1) has been linked to pulmonary hypertension (PH) in experimental studies. However, the clinical relevance of Ang-1 as a biomarker in PH remains unknown. We aimed to investigate the prognostic and clinical significance of Ang-1 in PH using data from the prospectively recruiting Giessen PH Registry. METHODS Patients with suspected PH (without previous...